Product Description

Saferet Capsules


Micronized Isotretinoin - 10 / 20mg


It is a retinoid, meaning it derives from vitamin A and is found in small quantities naturally in the body.

Mechanism of action:


Isotretinoin's amplifies production of neutrophilgelatinase- associated lipocalin (NGAL) in the skin, which has been shown to reduce sebum production by inducing apoptosis in sebaceous gland cells while exhibiting an antimicrobial effect on Propionibacterium acnes. The drug decreases the size and sebum output of the sebaceous glands. Isotretinoin's combined impact on several acne's contributory factors distinguishes isotretinoin from alternative remedies such as antibiotics and accounts for its greater efficacy in severe, nodulocystic cases.



 Severe recalcitrant nodular acne and Unresponsive moderate acne


The recommended dosage range for Isotretinoin is 0.5 to 1 mg/kg given in 2 divided doses daily for 15 to 20 weeks. The initial dosage of Isotretinoin is 0.5 to 1 mg/kg/day.


Pregnant& Nursing women:

 Not recommended 

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