LOGISIL Capsules

LOGISIL Capsules

Product Description

Composition:

Calcium Dobesilate      500mg.             

Chemical Name:

Calcium 2, 5-dihydroxybenzene sulfonate. A synthetic product

         

Mechanism of action:

·       Calcium Dobesilate reduces capillary hyperpermeability, blood hyperviscosity and erythrocyte & platelet aggregation.

·       Calcium Dobesilate decreases the platelet aggregation by inhibiting platelet activation factor (PAF), which prevents the formation of thrombus and clears the obstructed flow.

·       Calcium Dobesilate reduces capillary hyper permeability by increasing the activity of endothelial Nitric oxide (NO) synthase in vascular endothelial cells, leads to increase in NO synthesis which relaxes the vessels, closes the gap & decreases the capillary hyperpermeability.

·       Calcium Dobesilate enhances the release of tissue of plasminogen activator (TPA) and thus increases fibrinolytic activity which prevents formation of thrombus.

·       Calcium Dobesilate decreases erythrocyte aggregation and hyperviscosity of blood by showing its antioxidant property, thereby inhibiting lipid peroxidation of erythrocyte membrane by oxygen free radicals. This increases erythrocyte membrane flexibility & prevents thrombus formation.

·       Calcium Dobesilate inhibits the formation of sorbitol by inhibiting aldose reducatse. This prevents two main pathophysiological reactions in the body, the polyol pathway& the subsequent glycation of proteins.

·       Calcium Dobesilate accelerates the collagen II fibrillogenesis, a major structural component of the arterial wall.

Pharmacokinetics:

·       Calcium Dobesilate has an excellent absorption from intestine; it attains peak plasma concentration in 6 hrs.

·       Calcium Dobesilate is well distributed in the body except brain.

·       Kidney is the chief site of metabolism, approximately 10% of drug is metabolised with in 24hrs

·       The plasma half of Calcium Dobesilate is 4.9hrs. with a range of 10-12hrs.

Adverse Reactions:

·       Drug induces fever, epigastric pain, gastric irritation, pruritis and skin rashes.

 

Cautions & Contraindications:

·       Contraindicated in patients hypersensitive to Calcium Dobesilate & in children.

Indications:

ØChronic Venous Insufficiency

ØHemorrhoids

ØVaricose Veins

ØDiabetic Complications

ØPPD

 

Dosage:

Drug should be taken after meals.

§  In Haemorrhoids:Logisil 1 capsule (500mg) twice daily for 3 weeks followed by 1capsule once daily.

 

§  In Varicose veins:Logisil 1 capsule (500mg) twice daily for 3 weeks followed by 1capsule once daily

 

§  In Diabetic Foot Ulcers:Logisil 1-2 capsule (500-1000mg) for 4-6 months followed by 1 capsule (500mg) once daily

 

§  In PPD (Dermatology disorders): Logisil 1 capsule (500mg) twice daily for 3 months

Storage:

·       Avoid exposure to heat, light and moisture and keep away from children.

Pack:

·       Pack 10*10


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