Bonixa-C Capsules

Bonixa-C Capsules

Product Description

Composition:

Calcitriol 0.25mcg, Zinc 7.5mg, Calcium citrate maleate 500 mg

Calcitriol:

Introduction: Calcitriol is the hormonally active form of vitamin D with three hydroxyl groups. Calcitriol is used to treat and preventlow levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substancesto control the amount of calcium in the blood) are not working normally. Low blood levels of calcium may cause bone disease. Calcitriolis in a class of medications called vitamins

 

Mechanism of action: Calcitriol's mechanism of action takes place through its specific receptors, the calcium-sensing receptor(CaR) and the Vitamin D Receptor (VDR). These two factors have an effect not only on its specific receptors, but also they can modifythe other receptor in a positive manner, promoting its actions and demonstrating a cooperative effect between the two henceincreases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, decreasing thetransfer of calcium from blood to the urine by the kidney, and increasing the release of calcium into the blood from bone.

Zinc:

×          Helps in treatment of rheumatoid and psoriatic arthritis Zinc is not only a critical factor in bone formation, it is also involved in the production of enzymes that recycle worn-out portions of bone protein and for the healing of injured bones.

×          There is a significant correlation between the amount of zinc in bones and their strength, and osteoporosis is associated with low zinc levels.

×          Speeds up wound healing process

×          Stimulates the immune system

×          Reduces tumor growth and aids in cancer treatment

×          Helps diabetes by promoting the formation of insulin

 

Calcium citrate maleate

Mechanism of action: Calcium citrate maleate is described as a metastable complex of calcium, citrate and malate or as aCalcium citrate malate is a water-soluble calcium supplement. Calcium citrate malate's bioavailability stems from its water-solubilityand its method of dissolution. When dissolved, it releases calcium ions and a calcium-citrate complex. Calcium ions are absorbed

directly into intestinal cells, and the citrate complex enters the body through para cellular absorption

 

Indications: Osteoporosis, Post menopausal Women, Low back pain

 

Pregnancy: Calcitriol has been assigned to pregnancy category C by the FDA. Animal studies have shown calcitriol to beteratogenic; resulting in external and skeletal abnormalities, when used at doses 4 to 15 times the recommended human dose. Thereare no controlled data in human pregnancy. Calcitriol should be used during pregnancy only when benefit outweighs the risk.

 

Nursing women: There are no data on the excretion of calcitriol into human milk. The manufacturer recommends that due to thepotential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue calcitriol,taking into account the importance of the drug to the mother.

 

Contraindications: Calcium Deposits in Soft Tissue, Arteriosclerosis with Occlusion of the Arteries, Malabsorption, KidneyStone, Kidney Disease, Sarcoidosis, Increased Calcium in the Blood from Sarcoidosis, Increased Activity of the ParathyroidGland, High Amount of Phosphate in the Blood, High Amount of Calcium in Urine, High Amount of Calcium in the Blood, Extreme

Loss of Body Water, Excessive Amount of Vitamin D in the BodyAllergies: Calcium vitamin D analogue

 

Side effects: Bowel Movement Changes (constipation), abdominal pain, bloating or cramping.Stomach irritation which may lead to nausea and vomiting.Severe side effects Hypercalcemia, or elevated calcium levels, may cause symptoms of confusion, heart rate irregularities,increased urination or kidney damage

Pack:10 capsules per strip


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