Imoprine Tablet

Imoprine Tablet

Product Description

Composition:

Azathioprine   IP       50mg.   

                                               

Mechanism of action:

·        Azathioprine is metabolized to 6-Mercapto Purine (MP) through reduction by glutathione and other sulphydryl containing compounds and then enzymatically converted into 6-thiouric acid, 6-methyl-MP, and 6-thioguanine (6-TG)

 

·        Ultimately, azathioprine can incorporate into the replicating DNA and it blocks the de novo pathway of purine synthesis.

 

·        This action results in the specific action towards lymphocytes due to their lack of a salvage pathway which results in blockade of DNA replication.

·        Consequently, blocking the synthesis of purine also hinders DNA synthesis and thus inhibits the proliferation of T & B cells

Indications:

ØImmunobullous disease

ØPemphigus vulgaris

ØChronic actinic dermatitis (Photodermatoses)

ØPsoriasis

ØEczema

ØVitiligo

ØAtopic Dermatitis

Dosage:

 

1mg-3.5mg /kg body weight*

·         Dosage should be calculated based on the TPMT levels.

 

Storage:

Keep your IMOPRINE tablets in the pack until it is time to take them.

Store below 25°C and out of reach of children. Avoid exposure to heat, light and moisture.

 

Cautions & Contraindications:

  • Azathioprine should not be used in pregnant nor should it not be handled by pregnant owners.
     
  • Azathioprine should not be used in patients with pre-existing liver disease if possible. (It should be noted that most patients starting azathioprine have been on prednisone or other steroids and will have elevations in liver enzymes as a result of steroid exposure. This is not the same as having pre-existing liver disease and does not represent a problem.)

Pack:

·        Pack 10*10


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