Logidruf Lotion

Logidruf Lotion

Product Description

Composition:

Piroctone olamine-0.5%, Ketoconazole-2%

Piroctoneolamine:

Introduction:Piroctoneolamine, also known as Octopirox (Clarian) and piroctone ethanolamine, is a compound sometimesused in the treatment of fungal infections. Piroctoneolamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.It is also known as second generation antidandruff agent. It is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc Pyrithione.

Mechanism of action:The scalp defends itself against microorganisms and fungus infections. The defense system protects thescalp against all kinds of influences that it is exposed to. Sometimes this defense system becomes weakened and a certain fungusinfection develops called PityrosporumOvale. This fungus infection causes considerable cell multiplication. The skin is no longer in aposition to defend itself; the scaling becomes rapid, and starts to gather on the scalp. A superfluous cell situation mixing with skinsebum causes dandruff to be formed.

People with dandruff experience itchiness of the scalp. Besides this, their problem is very often an ongoing one. Piroctoneolamine isan antidandruff active ingredient, soothes inflamed scalp and reduces flaking. It has a specific action against PityrosporumOvale, theagent responsible for the production of dandruff. The antidandruff product containing piroctoneolamine destroys the fungus infectionthat is responsible for the dandruff and works against the formation of new dandruff, makes the scalp stay clean, itch free and preventsthe formation of new dandruff.

Ketoconazole:

Introduction:Ketoconazole is a synthetic antifungal drug used to prevent and treat skin and fungal infections, especially inimmunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as antidandruffshampoo, topical cream, and oral table

Mechanism of action:As an antifungal, ketoconazole is structurally similar to imidazole and interferes with the fungal synthesisof ergosterol, a constituent of fungal cell membranes, as well as certain enzymes. As with all azoles antifungal agents, ketoconazoleworks principally by inhibiting the enzyme cytochrome P450 14-alpha-demethylase (P45014DM). This enzyme participates in thesterol biosynthesis pathway that leads from lanosterol to ergosterol. As an antiandrogen, ketoconazole operates through at least two mechanisms of action. First, and most notably, high oral doses ofketoconazole (e.g. 400 mg 3x/day) block both testicular and adrenal androgen biosynthesis, leading to a reduction in circulatingtestosterone levels. Ketoconazole produces this effect through inhibition of cytochrome P450 and 17, 20-lyase, which are involved inthe synthesis and degradation of steroids, including the precursors of testosterone.

Indications:Dandruff, Seborrhoeic dermatitis, TineaVersicolor

Dosage and administration:Wash your hair or any affected skin with Logidruf shampoo and leave it for 3 to 5 minutes before rinsing. To start with, use Logidruf shampoo twice a week (every 3 or 4 days) for 2-4 weeks. After that, use the shampoo once every 1-2weeks to prevent the symptoms returning. If your hair requires washing between treatments, you can use an ordinary shampoo.

Pregnancy:No controlled studies are established. Consult to physician.

Side effects: Dryness of the skin on the scalp and it could itchy. Rashes and a tingling sensation

Storage:

Store below 250 C (77CF) & to protect from light.

Pack: 100ml


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