Product Description



Composition: LevocetirizineDihydrochloride 2.5mg, Ambroxol hydrochloride 15mg,

Guaiphensin 50mg


Introduction: Lejet –XP is a combination of levocetirizinedihydrochlorideabmroxol

hydrochloride and guaphensin. Levocetirizine is the R-enantiomer of cetirizine.

Levocetirizine is an orally active, potent, selective and long-acting H1-histamine

receptor antagonist, which has no anticholinergic effects. Ambroxol is an active Ndesmethyl metabolite of the mucolytic, bromhexine. It is an active mucolytic agent

and expectorant used in the treatment of acute and chronic disorders characterized

by the production of excess or thick mucus. Guaifenesin is used to help clear mucus

or phlegm (pronounced flem) from the chest when you have congestion from a cold

or flu. It works by thinning the mucus or phlegm in the lungs.


Levocetirizine: Levocetirizine, the (R) enantiomer of cetirizine, is a potent and

selective antagonist of peripheral H1-receptors. Binding studies revealed that

levocetirizine has high affinity for human H1 -receptors (Ki = 3.2 nmol/l). Levocetirizine has an affinity 2-fold higher than that of cetirizine (Ki = 6.3 nmol/l). Levocetirizine dissociates from H1 -receptors with a half-life of 115 ± 38 min. After single administration, levocetirizine shows receptor occupancy of 90% at 4 hours and 57% at 24 hours.


Ambroxol Hydrochloride: Ambroxol is an active N-desmethyl metabolite of the

mucolytic, bromhexine. Ambroxol is shown to exert several activities, as follows: Its

mucolytic activity by which it facilitates breakdown of acid mucopolysaccharidefibres

in the mucous making it thinner and less viscous and, therefore, easy for expectoration; it stimulates the ciliary activity thereby improving mucokinesis (transport of mucous); it stimulates production of pulmonary surfactant, a substance found to play a major role in the lung host defencemechanism,thereby further protecting against lung inflammation and infection; also exhibits anti-inflammatory and antioxidant activity. When dministered orally, onset of action occurs after about 30 minutes.Ambroxol is rapidly absorbed (70-80%) after oral administration. The time to reach peak plasma concentration is approximately 2 hours. The distribution half-life of ambroxol is around 1.3 hours Metabolite is dibromoanthranilic acid (activity unspecified).


Guaifenesin: Guaifenesinor guaiphenesin, also glycerylguaiacolateis

an expectorant drug sold over the counter and usually taken orally to assist the

bringing up (expectoration) of phlegm from the airways in acute respiratory tract

infections. Guaifenesin is thought to act as an expectorant by increasing the volume and

reducing the viscosity of secretions in the trachea and bronchi. It also stimulates the

flow of respiratory tract secretions, allowing ciliary movement to carry the loosened

secretions upward toward the pharynx. Thus, it may increase the efficiency of the

cough reflex and facilitate removal of the secretions; however, objective evidence for

this is limited and conflicting.


Indications: Rhinitis with productive cough, bronchitis, sinusitis, common cold and



Dosage and Administration:

Adults: 1 -2 spoon daily, should be administered orally.

Children 2 to 6 years old: 1 spoon daily, should be administered daily


Contraindications: Lejet-XP is contraindicated in patients with a history of

Hypersensitivity to any of the component of the product or its parent compounds. It is also contraindicated in patients with completely impaired renal function and with gastric



Warning and Precautions

Comparative clinical trials have revealed no evidence that levocetirizine at the

recommended dose impairs mental alertness, reactivity or the ability to drive. In

clinical trials the occurrence of somnolence, fatigue, and asthenia has been reported in

some patients under therapy with levocetirizine. Patients should be cautioned against

engaging in hazardous occupations requiring complete mental alertness, and motor

coordination such as operating machinery or driving a motor vehicle after ingestion

oflevocetirizine. Concurrent use of levocetirizine with alcohol or other central nervous

system depressants should be avoided because additional reductions in alertness

and additional impairment of central nervous system performance may occur.


Pregnancy: Ambroxol has not been shown to have any teratogenic or toxic effects

on the foetus.However, there are no adequate and well-controlled studies of

levocetirizine in pregnant women. Hence Lejet-XP should not be used during



Lactation: Since levocetirizine is expected to be excreted in breast-milk, the

combination is not recommended during lactation.


Adverse effects: Anaphylaxis, aggression, agitation, convulsion, visual

disturbances Palpitations, dyspnoea, nausea, hepatitis, angioneuroticoedema, fixed drug eruption, pruritus, rash, Urticaria, myalgia, are the very rare side effects associated with levocetirizine and ambroxol.


Storage Condition:

Store below 25 0 C (77CF) & to protect from light.


Pack: Bottle of 100ml

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