Nixitral Capsules

Nixitral Capsules

Product Description


Itraconazole – 100mg


Itraconazole is a synthetic triazole antifungal agent. It has three chiral centres and is a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs).It is a white to slightly yellowish powder, insoluble in water at pH 1-12, very slightly soluble in alcohols and freely soluble in dichloromethane.

Mechanism of Action:

In vitro studies have demonstrated that itraconazole inhibits the cytochrome P450-dependent synthesis of ergosterol, which is a vital component of fungal cell membranes.


The oral bioavailability of Itraconazole is maximal when it is taken without food. During chronic administration, steady state is reached after 1-2 weeks. Peak plasma levels are observed 2 hours (fasting) to 5 hours (with food) the bioavailability of Itraconazole is approximately 60% higher than the bioavailability of the capsule taken with a meal.The plasma protein binding of itraconazole is 99.8%. Concentrations of itraconazole in whole blood are 60% of those in plasma.Itraconazole is extensively distributed into tissues, which are prone to fungal invasion but only minimally into CSF or ocular fluid. Concentrations in lung, kidney, liver, bone, stomach, spleen and muscle were found to be two to three times higher than the corresponding plasma concentration.


·       Onychomycosis

·       Candidiasis

·       Aspergillosis

·       Sporotrichosis

·       Blastomycosis

·       Histoplamosis


Itraconazole is contraindicated in pregnant women except for the treatment of life-threatening cases of systemic mycoses, where the potential benefits outweigh the potential harm to the fetus.

Use in lactation

 The expected benefits of Itraconazole therapy should therefore be weighed against the potential risk of breast-feeding. In case of doubt, the patient should not breast-feed.

Adverse Reactions:

With the use of Itraconazole capsule the most frequently reported adverse reactions were of gastrointestinal origin, such as diarrhoea, nausea, abdominal pain and vomiting. Less frequently reported adverse experiences include headache, reversible increases in hepatic enzymes, dizziness and allergic reactions (such as pruritis, rash, urticaria and angio-oedema).


4 Capsules/ strip and 5 strips/ box

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