Product Description


LevocetirizineDiydrochloride: 2.5 mgDiethylcarbamazine Citrate: 150mg




Introduction: Levocetirizine (as levocetirizinedihydrochloride) is a third-generation

non-sedative antihistamine, developed from the second-generation antihistamine

cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the Renantiomerof the cetirizine racemate.


Mechanism of action: Levocetirizine, the (R) enantiomer of cetirizine, is a potent

and selective antagonist of peripheral H1-receptors. Binding studies revealed that

levocetirizine has high affinity for human H1 -receptors. Levocetirizine has an affinity

2-fold higher than that of cetirizine .Levocetirizine dissociates from H1 -receptors

with a half-life of 115 ± 38 min. After single administration, levocetirizine shows

receptor occupancy of 90% at 4 hours and 57% at 24 hours. The onset of action of

levocetirizine 5 mg in controlling pollen-induced symptoms has been observed at 1

hour post drug intake in placebo controlled trials in the model of the allergen

challengechamber.In vitro studies (Boyden chambers and cell layers techniques)

show that levocetirizine inhibits eotaxin-induced eosinophil transendothelial migration

through both dermal and lung cells.




Introduction: Diethylcarbamazine (DEC) is an anthelmintic drug that does not

resemble other antiparasitic compounds. It is a synthetic organic compound which is

highly specific for several parasites like Wuchereria bancrofti, Brugiamalayi,

orBrugiatimori and does not contain any toxic metallic elements.

Diethycarbamazine is mainly used in filarial infections.


Mechanism of action: MOA of Diethylcarbamazine is not well understood yet but is

thought that it acts by inhibiting the metabolism of arachiodonic acid. In a new study

it is found that it interferes with the 5-lipooxygenase and COX-1 pathways.


Indications: Filariasis, Tropical eosinophillia


Dosage and Administration: It should be decided by the physician as per the body

weight. Generally It is prescribed 6mg/kg In filariasis and tropical eosinophillia.


Adverse effects: Hypersensitivity including anaphylaxis, aggression, agitation,

convulsion visual disturbances, palpitations are the side effects may be reported.


Pregnancy: Should be deferred in pregnancy

Lactation: No well controlled studies are established in lactating women, should be

avoided during the nursing period.


Contraindications: If having any hypersensitivity to any ingredient present in the



Pack: 1strip contains 10 tablets

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