Fenixa 120/180mg Tablet / Suspension 30mg

Fenixa 120/180mg Tablet / Suspension 30mg

Product Description


Fexofenadine: 120/180mg Tablets and 30mg for 5ml suspension


Introduction: Fexofenadine is a second generation antihistamine. It reduces allergy symptoms of hay fever (seasonal allergicrhinitis), and may reduce itching of the skin in people with chronic itchy skin rashes. Fexofenadine was approved by the FDA inJuly, 1995.


Mechanism of action:

Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for

example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells)and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell tobe "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing. Fexofenadine blocksone type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Unlikethe first generation antihistamines, fexofenadine does not readily enter the brain from the blood, and, therefore, they cause less




For treating allergy,

·         Idiopathic urticaria,

·         Seasonal allergic rhinitis and

·         Perennial allergic rhinitis


Dosage and administration for Tablets:

Orally administered.

For seasonal allergies the recommended dose for adults and children 12 years or older is 60 mg twice daily or 180 mgonce daily. Children 6-11 years of age should be given 30 mg twice daily.

For chronic urticaria, adults and children 12 years or older should use 60 mg twice daily, and children 6-11 years of age shoulduse 30 mg twice daily. Fexofenadine can be taken with or without food



It is not known if fexofenadine crosses the human placenta to the fetus. The molecular weight (about 538 for the

hydrochloride salt) is low enough, however, that transfer to the fetus should be expected.

No reports describing the use of fexofenadine during human pregnancy have been located. However, studies in rats found doserelatedembryo and fetal toxicity, but the risk to a human fetus cannot be assessed at this time. Because of the extensive human dataavailable, several reviews have recommended that oral first generation antihistamines (e.g., chlorpheniramine or tripelennamine)should be considered if antihistamine therapy during pregnancy (especially in the 1st trimester) is required (2,3 and 4). The secondgeneration agents, cetirizine or loratadine, were considered acceptable alternatives, except during the 1st trimester, if a firstgeneration antihistamine was not tolerated.



·         Do not use fexofenadine in patients with a history of terfenadine hypersensitivity due to the similarity in chemical structure.

·         Fexofenadine should be used cautiously in patients with renal impairment associated with renal disease or renal failure


Storage Condition:

Store below 25 0 C (77CF) & to protect from light.



Fenixatablets available as a strip of 10 tablets and suspension as 100ml pet bottle.

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